Het zal nog precies 40 dagen duren voordat Resident Evil 6 in de winkels ligt, maar ondertussen wordt er steeds meer en meer over de game bekend. Want deze zal geen domme run and gun titel worden, maar zelfs RPG achtige elementen krijgen. Want tijdens het spelen verdien je Skill Points die je doen levelen en waarmee je weer Skill Sets kan kopen die die karakter kan gebruiken of in real time uitwisselen met je AI of vriend/vriendin. Hoe alles in zijn werk gaat, kan je hier onder bekijken en lezen.

Much like in Resident Evil 5 where between chapters, you could purchase ammo, items, and weapon upgrades, in Resident Evil 6, Skills can be purchased. Skills vary from weapon attack bonuses to defense bonuses to increased ammo. Some Skills can also be leveled up for increased effectiveness. Skills can be purchased with Skill Points that are obtained by killing enemies and finding items.

Players can equip up to three Skills at a time in Skill Sets. At the start of the game, you can only have one Skill Set, but by clearing any one of the scenarios, you gain eight Skill Sets. Players can switch between Skill Sets at any time in the game (Note: The game does not pause when switching between Skill Sets, so do it when in cover) to give a more tactical edge depending on the situation. A damage and defense based Skill Set for boss fights, a ammo and accuracy based Skill Set for normal play, partner bonus based Skill Set for co-op play etc.