Na Mafia II zal de Playboy ook zijn intrede in Dead Rising 2 doen, want tijdens het spelen zal je dit wereldberoemde blad overal tegenkomen. Het is overigens niet bekend of de zombie Patricia Pay een cameo heeft in deze game.

Players that discover the Playboy magazine in the game will receive a unique and special upgrade for Chuck Greene, the main character in Dead Rising 2. Furthermore, players will come across Playboy ads and billboards that will feature specially selected issues from the magazine's 57-year history. The new magazine system for Dead Rising 2, which will feature Playboy along with various other publications, is an evolution of the popular book system from the original Dead Rising game. Along with the special Playboy issue, there will be a variety of different themed magazines that Chuck will be able to pick up for bonuses to use to help fend off the zombie hordes along the way.